about James Christenson Antibacterial Research and Consulting

Cutting Edge Preclinical Infection Modeling
We have been doing some fascinating and cutting edge anti-infective work. Not only are we conducting our standard workhorse models, such as Mouse Protection Test and Neutropenic Thigh, Cytodex bead, Bacterial Pneumonia, but we have been developing some customized and sophisticated infection models.

We specialize in the following:

SUTURE INFECTION IN RATS.
We developed and conducted a number of studies evaluating dermal staph infections associated with different sorts of unique suture technology. The histologic section shows the deep dermal suture abscess in an untreated lesion.

BACTERIAL ENDOCARDITIS IN RABBITS.
We optimized and conducted a number of studies evaluating test articles in a model of vegetative valvular endocarditis with staph infection in rabbits. We use a guided imaging method to place the intracardiac catheter.

OCULAR KERATITIS AND CONJUNCTIVITIES IN RABBITS.
We optimized and conducted a number of studies evaluating treatment regimes in bacterial and viral infection of the damaged cornea and conjunctiva in rabbits. In addition to creating the corneal lesion, we used sophisticated imaging of the cornea and anterior segment.

Contact us for more information on our infection modeling.








Skin-healed lesion following Staphylococcal suture infection and treatment with high dose novel antibiotic. The lesion is completely healed and free of infection.







Skin and subcutis-no antibiotic treatment: Staphylococcal suture infection with foreign body reaction and severe chronic inflammation, bacterial colonization and fibrosis.







Skin and subcutis-no antibiotic treatment: Staphylococcal suture infection with extensive foreign body reaction and severe chronic inflammation, bacterial colonization and fibrosis.







Skin and subcutis-low dose antibiotic treatment: healed lesion following Staphylococcal suture infection and treatment with novel antibiotic. The lesion is completely healed but there is residual inflammation, fibrosis and vascular change.







Epidermis with inflammation secondary to epidermal infection. The epidermis is markedly thickened with inflammation and cellular proliferation.


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